Life as a biology major

"In our experiment, we hypothesized that obesity, type I diabetes and similar health issues were correlated with depleted levels of Akkermansia Muciniphila in the gut microbiome. In our experiments, we found that mice who were genetically predisposed to obesity had A. Muciniphila levels between 6 and 8, (log base 10) whereas lean mice had levels around 11, (figure A) which confirmed our hypothesis that A. Muciniphila levels are correlated with obesity. We tested then to see how prebiotic oligosaccharides would affect the levels of A. Muciniphila in mice. We found that in obese mice, prebiotic oligosaccharides supplemented to a control diet increased A. Muciniphila levels slightly from about 9 in control diet alone to about 10. When prebiotic oligosaccharides were supplemented with a high-fat diet, A. Muciniphila levels increased dramatically from around 7 in high-fat diet alone to about 10.5. (Figure B) Furthermore, we found that levels of lipopolysaccharides in the blood, which is indicative of endotoxicity, decreased with the introduction of prebiotic oligosaccharides into a control diet. With the lean mice, LPS dropped from around 1 to about .8; in the obese mice, LPS levels decreased from around 3, to the control baseline of 1. (Figure D) This suggests that as A. Muciniphila levels in the gut microbiome increase, the permeability of the guy decreases, thus inhibiting endotoxicity and obesity, type I diabetes and other similar conditions."

That fact that all of that makes sense to me, is kinda troubling.